When I first heard about Kratom back in August, I was skeptical, but I was intrigued.
The herb has been touted as an alternative to prescription painkillers and its effects have been touted to help treat opioid addiction and help people with chronic pain.
But the substance’s effects have remained largely unknown until now, with no studies looking at its health effects or whether it actually works.
Now, a study published in the Journal of Pharmacology and Experimental Therapeutics has provided a few insights into the health benefits of Kratom.
Kratom has been shown to increase opioid receptor levels in rats, but its effects on opioid receptors have not been studied.
The study analyzed the effects of Kava and morphine on rats’ opioid receptor expression levels in a concentration-dependent manner.
The results showed that Kratom increased the expression of opioid receptor subunits in the dorsal and ventral tegmental area of the hypothalamus, the part of the brain responsible for regulating appetite, sleep and other physiological functions.
In addition, the increase in opioid receptor mRNA in the hypothalamic area correlated with a decrease in opioid-receptor activity in the ventral part of that same area.
The researchers hypothesize that the increase of opioid receptors in the posterior part of hypothalamus could be a result of Karmac’s effects on the ventromedial hypothalamus.
The study was supported by the National Institutes of Health.
Read more about Kava: